Nanogels: Potential use in chronic endometritis and endometriosis in mares

Abstract

Equine endometritis is one of the main causes of disease in the mare, and it is the most important cause of reproductive failure. It is widely recognized by clinicians in mares susceptible to suffer it, after breeding, being characterized as persistent and recurring.
The conventional clinical therapies include, among others, the use of antibiotics, in combination with agents that can act synergistically with the antimicrobial therapy, for instance, compounds that act on biofilms, whit a lack of scientific evidence to demonstrate its safety in the endometrial epithelium. Nanomedicine provides novel nanotechnological tools to specific problems in the field of biomedicine. Nanogels are polymeric compounds, widely studied in medical applications, due to their water solubility, biocompatibility, functionalization capacity, bioactives transport, and ability to respond to external stimuli, among others. Based on the afore mentioned, we propose as the objective of this article, to analyze the potential uses of nanogels in mares for the treatment of endometritis and endometriosis, taking into account published bibliography on their use, as well as distinguishing favorable characteristics for this application. We highlight, based on current scientific evidence, that the use of nanogels could provide substantial advantages in the field of equine reproduction, associated with the therapeutic approach to endometritis, such as regenerative therapies for endometriosis.